Methylamine → HCID 89815338, compound

Participants

Reaction Conditions

Reaction Steps

Heat a solution of 5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2,4-difluorobenzenamine (0.55 g, 1.799 mmol) in methylamine (33% in EtOH, 10 mL, 1.799 mmol) at 120° C. with microwave irradiation for 12 h. Add additional methylamine (33% in EtOH, 2 mL), heat the mixture at 120° C. for 12 h, add more methylamine (33% in EtOH, 2 mL) and irradiate at 120° C. for 15 h. Dilute the mixture with EtOAc, wash with satd. NaHCO3 (2×), dry and evaporated to yield the title compound (0.53 g, 98%). MS(ESI) m/z: 301.1 (M+H+).

Provenance & Evidence