Isopropenyl chloroformate → HCID 89827812, compound

Participants

Reaction Steps

Treat a solution of 5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylaniline (0.5 g, 1.657 mmol) in EtOAc (10 mL) with satd. NaHCO3 (10 mL) followed by isopropenyl chloroformate (0.199 mL, 1.823 mmol) and stir the bi-phasic mixture at RT overnight. Separate the layers, extract the aqueous with EtOAc (2×), dry the combined organics over MgSO4 and concentrate to dryness to the title compound (646 mg, 101%). MS (ESI) m/z: 386.1 (M+H+).

Provenance & Evidence