Hydrochloric Acid → HCID 71735900, compound

Participants

Reaction Steps

Add HCl (3M, 4 mL, 12 mmol) to a suspension of N-(3-(3-(3-(3,3-dimethylbutyl)ureido)-4-fluorophenyl)-2-methyl-1,6-naphthyridin-7-yl)acetamide (70 mg, 0.160 mmol) in EtOH (4 mL), stir at RT for 1.5 h, then heat at 50° C. for 4 h. Cool to RT, remove the organics under reduced pressure and filter the aqueous residue. Add satd. NaHCO3 to the filtrate until pH=8, extract with THF (3×), wash the combined organics with brine, dry over MgSO4 and concentrate to dryness. Suspend the material in 4:1 MeCN/H2O, collect the solid via filtration and dry to afford the title compound (47 mg, 74%) as a golden-tan solid. MS (ESI) m/z: 396.2 (M+H+).

Provenance & Evidence