Isopropenyl chloroformate → HCID 89827818, compound

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Reaction Steps

Add isopropenyl chloroformate (0.193 mL, 1.769 mmol) to a 0° C. solution of 1-(5-(7-amino-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3,3-dimethylbutyl)urea (0.636 g, 1.608 mmol) in pyridine (10 mL) and stir the mixture for 1 h as it warms to RT. Add water, extract with DCM (3×), dry the combined organics over MgSO4 and concentrate to dryness to afford the title compound (585 mg, 76%). MS(ESI) m/z: 480.2 (M+H+).

Provenance & Evidence