HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-(2,2-Difluoroethoxy)-5-methylpyridin-3-yl)methanamine hydrochloride → 4-chloro-2-((6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-(2,2-Difluoroethoxy)-5-methylpyridin-3-yl)methanamine hydrochloride | HCID 87426846 | — |
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Product | 4-chloro-2-((6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one | HCID 89875176 | 44% |
Reaction Steps
The title compound is prepared in 44% yield (154 mg, pale yellow oil) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (279 mg, 1.0 mmol, Step-1 of Intermediate-1) and (6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl)methanamine hydrochloride (239 mg, 1.0 mmol, Amine-4) in a similar manner to Step-2 of Intermediate-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-5585ec0691254b53ac4e6835b39f4c81 |
| Source note | uspto-grants-2015_11 |