HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-(2,2,2-Trifluoroethoxy)phenyl)ethanamine hydrochloride → 4-chloro-2-(1-(4-(2,2,2-trifluoroethoxy)phenyl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-(2,2,2-Trifluoroethoxy)phenyl)ethanamine hydrochloride | HCID 67510126 | — |
| Reactant | Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate | HCID 72213786 | — |
| Product | 4-chloro-2-(1-(4-(2,2,2-trifluoroethoxy)phenyl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one | HCID 89874335 | 62% |
Reaction Steps
The title compound is prepared in 62% yield (131 mg, colorless amorphous solid) from methyl 3-(bromomethyl)-2-chloroisonicotinate (150 mg, 0.57 mmol) and 1-(4-(2,2,2-trifluoroethoxy)phenyl)ethanamine hydrochloride (124 mg, 0.57 mmol, Amine-10, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-d4b0011b2d95442aa04ec53478598c52 |
| Source note | uspto-grants-2015_11 |