HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine → 4-chloro-2-((2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine | HCID 67509640 | — |
| Reactant | Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate | HCID 72213786 | — |
| Product | 4-chloro-2-((2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one | HCID 89874121 | 80% |
Reaction Steps
The title compound is prepared in 80% yield (177 mg, colorless oil) from methyl 3-(bromomethyl)-2-chloroisonicotinate (150 mg, 0.57 mmol) and (2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine (155 mg, 0.57 mmol, Amine-13) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-570e8d783809445f9eade547b1fabbba |
| Source note | uspto-grants-2015_11 |