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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715230Generated: October 29, 2026

HCID 67510674, compound → HCID 89874175, compound

https://huagongshe.com/reaction/715230

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 67510674HCID 67510674—
ReactantMethyl 3-(bromomethyl)-2-chloropyridine-4-carboxylateHCID 72213786—
ProductHCID 89874175HCID 8987417546%

Reaction Steps

The title compound is prepared in 46% yield (98 mg, colorless oil) from methyl 3-(bromomethyl)-2-chloroisonicotinate (150 mg, 0.57 mmol) and (5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (148 mg, 0.57 mmol, Amine-22) in a similar manner to Intermediate-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187475B2
Source datasetuspto-grants-2015_11
ORD IDord-efad699f43014b29a645b2997c2a9405
Source noteuspto-grants-2015_11