HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate → HCID 89875391, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate | HCID 72213786 | — |
| Reactant | HCID 87426806 | HCID 87426806 | — |
| Product | HCID 89875391 | HCID 89875391 | 99% |
Reaction Steps
The title compound is prepared in >99% yield (340 mg, colorless oil) from methyl 3-(bromomethyl)-2-chloroisonicotinate (214 mg, 0.81 mmol) and 1-(3-chloro-4-(2,2-difluoroethoxy)phenyl)ethanamine hydrochloride (200 mg, 0.74 mmol, Amine-24, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-434a76a53c684df1a9086d4e2f49f0f6 |
| Source note | uspto-grants-2015_11 |