HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67510435, compound → HCID 89875249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67510435 | HCID 67510435 | — |
| Reactant | Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate | HCID 72213786 | — |
| Product | HCID 89875249 | HCID 89875249 | 55% |
Reaction Steps
The title compound is prepared in 55% yield (127 mg, colorless oil) from methyl 3-(bromomethyl)-2-chloroisonicotinate (150 mg, 0.57 mmol) and 1-(3-chloro-4-(2,2,2-trifluoroethoxy)phenyl)ethanamine hydrochloride (165 mg, 0.57 mmol, Amine-28, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-44660092e4e34249bb7790aa87d12206 |
| Source note | uspto-grants-2015_11 |