HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate → HCID 89875070, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate | HCID 72213786 | — |
| Reactant | HCID 87426425 | HCID 87426425 | — |
| Product | HCID 89875070 | HCID 89875070 | 85% |
Reaction Steps
The title compound is prepared in 85% yield (177 mg, colorless oil) from methyl 3-(bromomethyl)-2-chloroisonicotinate (150 mg, 0.57 mmol) and 1-(3-(2,2-difluoroethoxy)-5-methylphenyl)ethanamine hydrochloride (143 mg, 0.57 mmol, Amine-30, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ca34a268cbb4462f9dcae63ed0e10d42 |
| Source note | uspto-grants-2015_11 |