Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate → HCID 89874850, compound

HRID 715239Notes

Reaction equation

HRID 715239 reaction equation
Br[CH2:2][C:3]1[C:12]([Cl:13])=[N:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=O.Cl.[F:15][CH:16]([F:29])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][NH2:26])=[CH:21][C:20]=1[O:27][CH3:28]>>[Cl:13][C:12]1[C:3]2[CH2:2][N:26]([CH2:25][C:22]3[CH:23]=[CH:24][C:19]([O:18][CH2:17][CH:16]([F:29])[F:15])=[C:20]([O:27][CH3:28])[CH:21]=3)[C:5](=[O:7])[C:4]=2[CH:9]=[CH:10][N:11]=1

Participants

3

Reactant 2

HCID 72213786Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylateHCID 87426424HCID 87426424, compound

Product 1

HCID 89874850HCID 89874850, compoundYield 35%

Procedure

The title compound is prepared in 35% yield (74 mg, white solid) from methyl 3-(bromomethyl)-2-chloroisonicotinate (150 mg, 0.57 mmol) and (4-(2,2-difluoroethoxy)-3-methoxyphenyl)methanamine hydrochloride (144 mg, 0.57 mmol, Amine-32) in a similar manner to Intermediate-2.

Sources & evidence

ORD record
ord-f5ad95dae7cb4c798235483651d94bb3
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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