(3-Chloro-4-(2,2-difluoroethoxy)phenyl)methanamine hydrochloride → 4-chloro-2-(3-chloro-4-(2,2-difluoroethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one

HRID 715243노트

반응식

HRID 715243 반응식
Br[CH2:2][C:3]1[C:13]([Cl:14])=[N:12][CH:11]=[CH:10][C:4]=1[C:5]([O:7]CC)=O.Cl.[Cl:16][C:17]1[CH:18]=[C:19]([CH2:28][NH2:29])[CH:20]=[CH:21][C:22]=1[O:23][CH2:24][CH:25]([F:27])[F:26]>>[Cl:14][C:13]1[C:3]2[CH2:2][N:29]([CH2:28][C:19]3[CH:20]=[CH:21][C:22]([O:23][CH2:24][CH:25]([F:26])[F:27])=[C:17]([Cl:16])[CH:18]=3)[C:5](=[O:7])[C:4]=2[CH:10]=[CH:11][N:12]=1

참가 물질

3

반응물 2

HCID 87426940(3-Chloro-4-(2,2-difluoroethoxy)phenyl)methanamine hydrochlorideHCID 89874240Ethyl 3-(bromomethyl)-2-chloroisonicotinate

생성물 1

HCID 898747094-chloro-2-(3-chloro-4-(2,2-difluoroethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one수율 84%

실험 절차

The title compound is prepared in 84% yield (225 mg, colorless amorphous solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (200 mg, 0.72 mmol) and (3-chloro-4-(2,2-difluoroethoxy)phenyl)methanamine hydrochloride (195 mg, 0.75 mmol, Amine-33) in a similar manner to Intermediate-2.

출처 및 근거

ORD 기록
ord-26f91f7a67bf43e28638cc0b95f77889
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187475B2

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