HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-(2,2-Difluoroethoxy)-5-methylpyridin-3-yl)ethanamine hydrochloride → 4-chloro-2-(1-(6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl)ethyl)-3-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-(2,2-Difluoroethoxy)-5-methylpyridin-3-yl)ethanamine hydrochloride | HCID 87426335 | — |
| Reactant | Methyl 3-(1-bromoethyl)-2-chloroisonicotinate | HCID 89875505 | — |
| Product | 4-chloro-2-(1-(6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl)ethyl)-3-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one | HCID 89874494 | 24% |
Reaction Steps
The title compound is prepared in 24% yield (134 mg, colorless amorphous solid) from methyl 3-(1-bromoethyl)-2-chloroisonicotinate (400 mg, 1.4 mmol, Step-1 of Intermediate-6, racemate) and 1-(6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl)ethanamine hydrochloride (399 mg, 1.6 mmol, Amine-5, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-7afd4dde5e894dcdb8310bbed2361fc8 |
| Source note | uspto-grants-2015_11 |