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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715251Generated: November 1, 2026

Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89875307, compound

https://huagongshe.com/reaction/715251

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(bromomethyl)-2-chloroisonicotinateHCID 89874240—
ReactantHCID 89875080HCID 89875080—
ProductHCID 89875307HCID 8987530761%

Reaction Steps

The title compound is prepared in 61% yield (260 mg, colorless amorphous solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (300 mg, 1.08 mmol) and 1-(5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethanamine hydrochloride (337 mg, 1.19 mmol, Amine-36, single enantiomer) in a similar manner to Intermediate-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187475B2
Source datasetuspto-grants-2015_11
ORD IDord-7ea8768241fb4ffea4874d22651cec5b
Source noteuspto-grants-2015_11