HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89875045, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Reactant | HCID 89875058 | HCID 89875058 | — |
| Product | HCID 89875045 | HCID 89875045 | 50% |
Reaction Steps
The title compound is prepared in 50% yield (140 mg, colorless amorphous solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (200 mg, 0.73 mmol, Step-1 of Intermediate-1) and 1-(6-(3-fluorophenoxy)-5-methylpyridin-3-yl)ethanamine hydrochloride (240 mg, 0.86 mmol, Amine-40, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-120e63debdac4b719b8ee5a8eed07e4a |
| Source note | uspto-grants-2015_11 |