HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 89874043, compound → HCID 89875093, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 89874043 | HCID 89874043 | — |
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Product | HCID 89875093 | HCID 89875093 | 59% |
Reaction Steps
The title compound is prepared in 59% yield (160 mg, colorless amorphous solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (200 mg, 0.72 mmol, Step-1 of Intermediate-1) and 1-(6-(4-chloro-1H-pyrazol-1-yl)-5-methylpyridin-3-yl)ethanamine hydrochloride (200 mg, 0.72 mmol, Amine-45, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-db59a3067186407a951fe78e53f44731 |
| Source note | uspto-grants-2015_11 |