HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89873957, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Reactant | HCID 89875036 | HCID 89875036 | — |
| Product | HCID 89873957 | HCID 89873957 | 62% |
Reaction Steps
The title compound is prepared in 62% yield (220 mg, pale yellow solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (260 mg, 0.93 mmol, Step-1 of Intermediate-1) and 5-(1-aminoethyl)-3-methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine hydrochloride (250 mg, 0.93 mmol, Amine-46, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-788e284e23034e59a1cbd4ceae5d14b8 |
| Source note | uspto-grants-2015_11 |