HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89874265, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Reactant | HCID 89874765 | HCID 89874765 | — |
| Product | HCID 89874265 | HCID 89874265 | 72% |
Reaction Steps
The title compound is prepared in 72% yield (360 mg, pale yellow solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (350 mg, 1.3 mmol, Step-1 of Intermediate-1) and (5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl)methanamine hydrochloride (410 mg, 1.3 mmol, Amine-52) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-d8a711af63a14f97be9f3e1de50558fd |
| Source note | uspto-grants-2015_11 |