Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715282Generated: October 30, 2026

Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89874291, compound

https://huagongshe.com/reaction/715282

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(bromomethyl)-2-chloroisonicotinateHCID 89874240—
ReactantHCID 89874258HCID 89874258—
ProductHCID 89874291HCID 8987429183%

Reaction Steps

The title compound is prepared in 83% yield (1200 mg, colorless amorphous solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (1000 mg, 3.6 mmol, Step-1 of Intermediate-1) and 1-(5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl)ethanamine hydrochloride (1030 mg, 3.6 mmol, Amine-63, single enantiomer) in a similar manner to Intermediate-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187475B2
Source datasetuspto-grants-2015_11
ORD IDord-f3a35c7db6a04bae8c3003f61d3a0e15
Source noteuspto-grants-2015_11