HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89874991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Reactant | HCID 89875372 | HCID 89875372 | — |
| Product | HCID 89874991 | HCID 89874991 | 44% |
Reaction Steps
The title compound is prepared in 44% yield (240 mg, pale brown solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (370 mg, 1.3 mmol, Step-1 of Intermediate-1) and 1-(5-chloro-6-((2,2,2-trifluoroethoxy)methyl)pyridin-3-yl)ethanamine hydrochloride (450 mg, 1.3 mmol, Amine-65, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-dc5020adb6b040d5ae56fe09099a6d07 |
| Source note | uspto-grants-2015_11 |