Phenyl formate → HCID 89875642, compound

HRID 715303Notes

Reaction equation

Cl[C:2]1[C:7]2[CH2:8][N:9]([CH2:12][C:13]3[CH:14]=[N:15][C:16]([O:20][CH2:21][C:22]([F:27])([F:26])[CH:23]([F:25])[F:24])=[C:17]([CH3:19])[CH:18]=3)[C:10](=[O:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH:28]([O:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:29]>>[CH3:19][C:17]1[CH:18]=[C:13]([CH2:12][N:9]2[C:10](=[O:11])[C:6]3[CH:5]=[CH:4][N:3]=[C:2]([C:28]([O:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:29])[C:7]=3[CH2:8]2)[CH:14]=[N:15][C:16]=1[O:20][CH2:21][C:22]([F:27])([F:26])[CH:23]([F:25])[F:24]

Participants

Reactant 2

HCID 74626Phenyl formate

HCID 89873995HCID 89873995, compound

Product 1

HCID 89875642HCID 89875642, compoundYield 71%

Procedure

The title compound is prepared in 71% yield (220 mg, yellow oil) from 4-chloro-2-((5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one (250 mg, 0.62 mmol, Intermediate-68) and phenyl formate (150 mg, 1.2 mmol) in a similar manner to Intermediate-91.

Sources & evidence

ORD record: ord-50c8e57529bf411d90936d237ab8dc17
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09187475B2

Reaction notes

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