Phenyl formate → HCID 89875062, compound

HRID 715307Notes

Reaction equation

HRID 715307 reaction equation
Cl[C:2]1[C:7]2[CH2:8][N:9]([CH2:12][C:13]3[CH:14]=[N:15][C:16]([N:20]4[CH:24]=[CH:23][CH:22]=[N:21]4)=[C:17]([CH3:19])[CH:18]=3)[C:10](=[O:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH:25]([O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:26]>>[CH3:19][C:17]1[CH:18]=[C:13]([CH2:12][N:9]2[C:10](=[O:11])[C:6]3[CH:5]=[CH:4][N:3]=[C:2]([C:25]([O:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[O:26])[C:7]=3[CH2:8]2)[CH:14]=[N:15][C:16]=1[N:20]1[CH:24]=[CH:23][CH:22]=[N:21]1

Participants

3

Reactant 2

HCID 74626Phenyl formateHCID 89874795HCID 89874795, compound

Product 1

HCID 89875062HCID 89875062, compoundYield 75%

Procedure

The title compound is prepared in 75% yield (240 mg, brown solid) from 4-chloro-2-((5-methyl-6-(1H-pyrazol-1-yl)pyridin-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one (250 mg, 0.74 mmol, Intermediate-70) and phenyl formate (180 mg, 1.5 mmol) in a similar manner to Intermediate-91.

Sources & evidence

ORD record
ord-a77e35fb39434b3fa6bd66c8693b00d6
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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