Phenyl formate → HCID 89874741, compound

HRID 715310Notes

Reaction equation

Cl[C:2]1[C:7]2[CH2:8][N:9]([CH2:12][C:13]3[CH:18]=[C:17]([CH3:19])[C:16]([O:20][CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:15][N:14]=3)[C:10](=[O:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH:27]([O:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:28]>>[CH3:19][C:17]1[C:16]([O:20][CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:15][N:14]=[C:13]([CH2:12][N:9]2[C:10](=[O:11])[C:6]3[CH:5]=[CH:4][N:3]=[C:2]([C:27]([O:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:28])[C:7]=3[CH2:8]2)[CH:18]=1

Participants

Reactant 2

HCID 74626Phenyl formate

HCID 89875217HCID 89875217, compound

Product 1

HCID 89874741HCID 89874741, compoundYield 41%

Procedure

The title compound is prepared in 41% yield (30 mg, white solid) from 4-chloro-2-((4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one (60 mg, 0.16 mmol, Intermediate-75) and phenyl formate (38 mg, 0.31 mmol) in a similar manner to Intermediate-91.

Sources & evidence

ORD record: ord-34367a35d9ec4e79975b684cde84deee
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09187475B2

Reaction notes

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