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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715321Generated: October 29, 2026

Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89874300, compound

https://huagongshe.com/reaction/715321

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(bromomethyl)-2-chloroisonicotinateHCID 89874240—
ReactantHCID 89875073HCID 89875073—
ProductHCID 89874300HCID 8987430092%

Reaction Steps

The title compound is prepared in 92% yield (683 mg, colorless amorphous) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (500 mg, 1.80 mmol, Step-1 of Intermediate-1) and 1-(6-((4-fluorobenzyl)oxy)-5-methylpyridin-3-yl)ethanamine (240 mg, 0.86 mmol, Amine-71, single enantiomer) in a similar manner to Intermediate-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187475B2
Source datasetuspto-grants-2015_11
ORD IDord-a168b50acd0f4b32bda234410e8cc0ef
Source noteuspto-grants-2015_11