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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715322Generated: October 30, 2026

HCID 89873997, compound → HCID 89874914, compound

https://huagongshe.com/reaction/715322

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 89873997HCID 89873997—
ReactantEthyl 3-(bromomethyl)-2-chloroisonicotinateHCID 89874240—
ProductHCID 89874914HCID 8987491471%

Reaction Steps

The title compound is prepared in 71% yield (490 mg, yellow oil) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (460 mg, 1.65 mmol, Step-1 of Intermediate-1) and 1-(4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl)ethanamine hydrochloride (500 mg, 1.65 mmol, Amine-72, single enantiomer) in a similar manner to Intermediate-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187475B2
Source datasetuspto-grants-2015_11
ORD IDord-b48d724868d743cf8801ab87a394fc9e
Source noteuspto-grants-2015_11