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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715327Generated: October 30, 2026

Ethyl 3-(bromomethyl)-2-chloroisonicotinate → HCID 89874728, compound

https://huagongshe.com/reaction/715327

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(bromomethyl)-2-chloroisonicotinateHCID 89874240—
ReactantHCID 89875078HCID 89875078—
ProductHCID 89874728HCID 8987472874%

Reaction Steps

The title compound is prepared in 74% yield (612 mg, orange oil) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (605 mg, 2.17 mmol, Step-1 of Intermediate-1) and 1-(5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl)ethanamine hydrochloride (600 mg, 1.98 mmol, Amine-77, single enantiomer) in a similar manner to Intermediate-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187475B2
Source datasetuspto-grants-2015_11
ORD IDord-e192fa2c61c04e9789f5f68845c5b8fb
Source noteuspto-grants-2015_11