Phenyl formate → HCID 89875195, compound

HRID 715335Notes

Reaction equation

HRID 715335 reaction equation
Cl[C:2]1[C:7]2[CH2:8][N:9]([CH:12]([C:14]3[CH:15]=[N:16][C:17]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=4)=[C:18]([CH3:20])[CH:19]=3)[CH3:13])[C:10](=[O:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH:30]([O:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31]>>[F:29][C:26]1[CH:27]=[CH:28][C:23]([CH2:22][O:21][C:17]2[N:16]=[CH:15][C:14]([CH:12]([N:9]3[C:10](=[O:11])[C:6]4[CH:5]=[CH:4][N:3]=[C:2]([C:30]([O:32][C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[O:31])[C:7]=4[CH2:8]3)[CH3:13])=[CH:19][C:18]=2[CH3:20])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 74626Phenyl formateHCID 89874300HCID 89874300, compound

Product 1

HCID 89875195HCID 89875195, compoundYield 86%

Procedure

The title compound is prepared in 86% yield (287 mg, brown oil) from 4-chloro-2-(1-(6-((4-fluorobenzyl)oxy)-5-methylpyridin-3-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one (276 mg, 0.67 mmol, Intermediate-125, single enantiomer) and phenyl formate (164 mg, 1.34 mmol) in a similar manner to Intermediate-91.

Sources & evidence

ORD record
ord-c76375b123014510b4f4417741e36aa8
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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