HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 89874055, compound → HCID 89875539, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 89874055 | HCID 89874055 | — |
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Product | HCID 89875539 | HCID 89875539 | 59% |
Reaction Steps
The title compound is prepared in 59% yield (331 mg, colorless oil) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (389 mg, 1.40 mmol, Step-1 of Intermediate-1) and 1-(3-chloro-4-(2,2-difluoropropoxy)phenyl)ethanamine hydrochloride (400 mg, 1.40 mmol, Amine-85, single enantiomer) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-932529373a974f7688a4c77a478bfe21 |
| Source note | uspto-grants-2015_11 |