tert-Butylsulfinamide, (R)-(+)- → HCID 87426852, compound

HRID 715353Notes

Reaction equation

HRID 715353 reaction equation
[F:1][C:2]([F:17])([CH:14]([F:16])[F:15])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1.[CH3:18][C:19]([S@:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>>[CH3:18][C:19]([S@:22]([NH:24][CH:11]([C:8]1[CH:9]=[N:10][C:5]([O:4][CH2:3][C:2]([F:17])([F:1])[CH:14]([F:16])[F:15])=[CH:6][CH:7]=1)[CH3:12])=[O:23])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 81896862HCID 81896862, compound

Product 1

HCID 87426852HCID 87426852, compoundYield 76%

Procedure

The title compound is prepared in 76% yield (6.0 g, pale brown oil) from 1-(6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl)ethanone (5.6 g, 22.2 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-c37e1791b08d45839b012106125bfb62
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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