tert-Butylsulfinamide, (R)-(+)- → HCID 67509434, compound

HRID 715359Notes

Reaction equation

HRID 715359 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15](=O)[CH3:16])[CH:6]=[N:7][C:8]=1[O:9][CH2:10][C:11]([F:14])([F:13])[F:12].[CH3:18][C:19]([S@:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]([NH:24][S@@:22]([C:19]([CH3:21])([CH3:20])[CH3:18])=[O:23])[CH3:16])[CH:6]=[N:7][C:8]=1[O:9][CH2:10][C:11]([F:14])([F:13])[F:12]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67509377HCID 67509377, compound

Product 1

HCID 67509434HCID 67509434, compoundYield 83%

Procedure

The title compound is prepared in 83% yield (0.29 g, white solid) from 1-(5-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanone (0.25 g, 0.99 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-4f6857b4f014440d92e1f584a78d2d5e
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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