tert-Butylsulfinamide, (R)-(+)- → HCID 67509888, compound

HRID 715370Notes

Reaction equation

HRID 715370 reaction equation
[F:1][C:2]([F:16])([F:15])[CH2:3][CH2:4][O:5][C:6]1[N:11]=[CH:10][C:9]([C:12](=O)[CH3:13])=[CH:8][CH:7]=1.[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@:21]([NH:23][CH:12]([C:9]1[CH:10]=[N:11][C:6]([O:5][CH2:4][CH2:3][C:2]([F:16])([F:15])[F:1])=[CH:7][CH:8]=1)[CH3:13])=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67508859HCID 67508859, compound

Product 1

HCID 67509888HCID 67509888, compoundYield 80%

Procedure

The title compound is prepared in 80% yield (0.95 g, white solid) from 1-(6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethanone (0.82 g, 3.51 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-6786b8813c0144c79bf2c25f6fe0d53b
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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