HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide → 1-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide | HCID 86707284 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Product | 1-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)propan-1-one | HCID 67509769 | 87% |
Reaction Steps
The title compound is prepared in 87% yield (0.53 g, colorless oil) from N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy)nicotinamide (0.70 g, 2.65 mmol, Step-2 of Amine-1) and ethyl magnesium bromide instead of methyl magnesium bromide in a similar manner to Step-3 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-135fae8fe9324ab2abba2d3d4dabcb0e |
| Source note | uspto-grants-2015_11 |