HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butylsulfinamide, (R)-(+)- → (R)-2-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propyl)propane-2-sulfinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butylsulfinamide, (R)-(+)- | HCID 10964479 | — |
| Reactant | 1-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)propan-1-one | HCID 67509769 | — |
| Product | (R)-2-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propyl)propane-2-sulfinamide | HCID 67509323 | 50% |
Reaction Steps
The title compound is prepared in 50% yield (0.39 g, colorless oil) from 1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propan-1-one (0.54 g, 2.29 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-d39cd0ac54ba47248a831ecb722b4d3c |
| Source note | uspto-grants-2015_11 |