tert-Butylsulfinamide, (R)-(+)- → HCID 87426975, compound

HRID 715384Notes

Reaction equation

HRID 715384 reaction equation
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[N:10]=[C:9]([O:11][CH3:12])[C:8]([C:13](=O)[CH3:14])=[CH:7][CH:6]=1.[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[N:10]=[C:9]([O:11][CH3:12])[C:8]([CH:13]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:14])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426861HCID 87426861, compound

Product 1

HCID 87426975HCID 87426975, compoundYield 73%

Procedure

The title compound is prepared in 73% yield (400 mg, clear colorless oil) from 1-(6-(2,2-difluoroethoxy)-2-methoxypyridin-3-yl)ethanone (380 mg, 1.6 mmol, Step-5) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-5a0d863711b247b48391fb7b6161b183
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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