tert-Butylsulfinamide, (R)-(+)- → HCID 87427002, compound

HRID 715396Notes

Reaction equation

HRID 715396 reaction equation
[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:12](=O)[CH3:13])[CH:8]=[C:9]([CH3:11])[CH:10]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:12]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:13])[CH:8]=[C:9]([CH3:11])[CH:10]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87427008HCID 87427008, compound

Product 1

HCID 87427002HCID 87427002, compoundYield 77%

Procedure

The title compound is prepared in 77% yield (0.85 g, colorless oil) from 1-(3-(2,2-difluoroethoxy)-5-methylphenyl)ethanone (1.06 g, 3.04 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-0408e18164da49a1850bf1fd827dd987
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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