tert-Butylsulfinamide, (R)-(+)- → HCID 87427300, compound

HRID 715397Notes

Reaction equation

HRID 715397 reaction equation
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][C:6]=1[O:14][CH3:15].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:12])=[CH:7][C:6]=1[O:14][CH3:15]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 50896805HCID 50896805, compound

Product 1

HCID 87427300HCID 87427300, compoundYield 97%

Procedure

The title compound is prepared in 97% yield (1.09 g, yellow oil) from 1-(4-(2,2-difluoroethoxy)-3-methoxyphenyl)ethanone (0.77 g, 3.35 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-3c23e83821e2404ea7a9fa9e0f2d4b36
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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