HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoroethyl trifluoromethanesulfonate → 2-Chloro-5-(2,2-difluoroethoxy)-4-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoroethyl trifluoromethanesulfonate | HCID 2774089 | — |
| Reactant | 2-Chloro-5-hydroxy-4-methylpyridine | HCID 71299549 | — |
| Product | 2-Chloro-5-(2,2-difluoroethoxy)-4-methylpyridine | HCID 89875518 | 95% |
Reaction Steps
The title compound is prepared in 95% yield (4.14 g, white solid) from 6-chloro-4-methylpyridin-3-ol (3.0 g, 20.9 mmol) and 2,2-difluoroethyl trifluoromethanesulfonate (4.92 g, 23.0 mmol) in a similar manner to Step-1 of Amine-49.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-eaabdeb5e15f420f88e027d2dd668752 |
| Source note | uspto-grants-2015_11 |