tert-Butylsulfinamide, (R)-(+)- → HCID 89873970, compound

HRID 715433Notes

Reaction equation

HRID 715433 reaction equation
[F:1][CH:2]([F:14])[CH2:3][O:4][C:5]1[C:6]([CH3:13])=[CH:7][C:8]([CH:11]=O)=[N:9][CH:10]=1.[CH3:15][C:16]([S@:19]([NH2:21])=[O:20])([CH3:18])[CH3:17]>>[F:1][CH:2]([F:14])[CH2:3][O:4][C:5]1[C:6]([CH3:13])=[CH:7][C:8](/[CH:11]=[N:21]/[S@@:19]([C:16]([CH3:18])([CH3:17])[CH3:15])=[O:20])=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874330HCID 89874330, compound

Product 1

HCID 89873970HCID 89873970, compoundYield 11%

Procedure

The title compound is prepared in 11% yield (147 mg, colorless oil) from 5-(2,2-difluoroethoxy)-4-methylpicolinaldehyde (860 mg, 4.27 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide (777 mg, 6.41 mmol) in a similar manner to Step-6 of Amine-49.

Sources & evidence

ORD record
ord-f189d8417b9f429190797a4be2520a2e
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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