tert-Butylsulfinamide, (R)-(+)- → HCID 89874810, compound

HRID 715438Notes

Reaction equation

HRID 715438 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])=[CH:6][N:5]=[C:4]([CH:15]=O)[CH:3]=1.[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@@:21](/[N:23]=[CH:15]/[C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([O:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])=[CH:6][N:5]=1)=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874165HCID 89874165, compound

Product 1

HCID 89874810HCID 89874810, compoundYield 65%

Procedure

The title compound is prepared in 65% yield (1.67 g, white solid) from 4-methyl-5-(3,3,3-trifluoropropoxy)picolinaldehyde (1.79 g, 7.68 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide (1.40 g, 11.5 mmol) in a similar manner to Step-6 of Amine-49.

Sources & evidence

ORD record
ord-13748b0df45346dc9a39f567e9dbf105
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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