HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6-Dichloronicotinic acid → 5-Chloro-6-(2,2-difluoropropoxy)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6-Dichloronicotinic acid | HCID 247987 | — |
| Reactant | 2,2-Difluoropropanol | HCID 13394818 | — |
| Product | 5-Chloro-6-(2,2-difluoropropoxy)nicotinic acid | HCID 89873804 | 85% |
Reaction Steps
The title compound is prepared in 85% yield (1.12 g, colorless oil) from 5,6-dichloronicotinic acid (1.00 g, 5.21 mmol) and 2,2-difluoropropan-1-ol (0.50 g, 5.21 mmol) in a similar manner to Step-1 of Intermediate-A3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-fa7dde917d214b3db13b91ea4be95c44 |
| Source note | uspto-grants-2015_11 |