tert-Butylsulfinamide, (R)-(+)- → HCID 117974149, compound

HRID 715442Notes

Reaction equation

HRID 715442 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:14](=O)[CH3:15])[CH:5]=[N:6][C:7]=1[CH2:8][CH2:9][C:10]([F:13])([F:12])[F:11].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@:21]([NH:23][CH:14]([C:4]1[CH:5]=[N:6][C:7]([CH2:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[C:2]([CH3:1])[CH:3]=1)[CH3:15])=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874216HCID 89874216, compound

Product 1

HCID 117974149HCID 117974149, compoundYield 57%

Procedure

The title compound is prepared in 57% yield (700 mg, white solid) from 1-(5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl)ethanone (850 mg, 3.68 mmol, Step-5) and (R)-2-methylpropane-2-sulfinamide (668 mg, 5.51 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-13d7b08598c442fc81dabb79272f43b1
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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