HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Ethyl 5-chloro-6-(chloromethyl)pyridine-3-carboxylate--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 89875094 | HCID 89875094 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 5-chloro-6-(chloromethyl)pyridine-3-carboxylate--hydrogen chloride (1/1) | HCID 71744190 | 193.3% |
Reaction Steps
To a solution of ethyl 5-chloro-6-(hydroxymethyl)nicotinate (990 mg, 4.59 mmol, Step-2) in DCM (20 mL) is added thionyl chloride (0.80 mL, 9.2 mmol) at 0° C. After stirring at rt for 2 hours, the solvent is removed in vacuo to give 1.20 g (97% yield) of the title compound as brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-05701a66edbc459bba2e38445538cce1 |
| Source note | uspto-grants-2015_11 |