tert-Butylsulfinamide, (R)-(+)- → HCID 89875339, compound

HRID 715447Notes

Reaction equation

HRID 715447 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:13](=O)[CH3:14])[CH:5]=[N:6][C:7]=1[N:8]1[CH:12]=[CH:11][CH:10]=[N:9]1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH3:16][C:17]([S@:20]([NH:22][CH:13]([C:4]1[CH:5]=[N:6][C:7]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)=[C:2]([CH3:1])[CH:3]=1)[CH3:14])=[O:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875034HCID 89875034, compound

Product 1

HCID 89875339HCID 89875339, compoundYield 79%

Procedure

The title compound is prepared in 79% yield (1.11 g, colorless oil) from 1-(5-methyl-6-(1H-pyrazol-1-yl)pyridin-3-yl)ethanone (920 mg, 4.57 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide (665 mg, 5.49 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-1ada266bd8aa44b2a2c73c2c91f583e9
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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