tert-Butylsulfinamide, (R)-(+)- → HCID 89874098, compound

HRID 715448Notes

Reaction equation

HRID 715448 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:14](=O)[CH3:15])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@:21]([NH:23][CH:14]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[C:2]([CH3:1])[CH:3]=1)[CH3:15])=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874788HCID 89874788, compound

Product 1

HCID 89874098HCID 89874098, compoundYield 64%

Procedure

The title compound is prepared in 64% yield (6.05 g, colorless oil) from 1-(3-methyl-4-(2,2,2-trifluoroethoxy)phenyl)ethanone (6.55 g, 28.2 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide (5.13 g, 42.3 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-0c12ce70dc6c4ccd8daaddc3effe0c63
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

Loading…