Aluminium lithium hydride → HCID 89875398, compound

HRID 715452Notes

Reaction equation

HRID 715452 reaction equation
CON(C)[C:4](=[O:20])[C:5]1[CH:10]=[C:9]([CH3:11])[C:8]([O:12][CH2:13][C:14]([F:19])([F:18])[CH:15]([F:17])[F:16])=[CH:7][N:6]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:11][C:9]1[C:8]([O:12][CH2:13][C:14]([F:19])([F:18])[CH:15]([F:17])[F:16])=[CH:7][N:6]=[C:5]([CH:4]=[O:20])[CH:10]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 89875474HCID 89875474, compound

Product 1

HCID 89875398HCID 89875398, compoundYield 99%

Procedure

The title compound is prepared in >99% yield (1.20 g, yellow solid) from N-methoxy-N,4-dimethyl-5-(2,2,3,3-tetrafluoropropoxy)picolinamide (1.36 g, 4.38 mmol, Step-4) and lithium aluminum hydride (83 mg, 2.2 mmol) in a similar manner to Step-2 of Amine-3.

Sources & evidence

ORD record
ord-10630740e0ce407aba22b589c03dd53f
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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