Aluminium lithium hydride → HCID 89874839, compound

HRID 715455Notes

Reaction equation

HRID 715455 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[C:7]([CH3:18])=[CH:8][C:9]([C:12](N(OC)C)=[O:13])=[N:10][CH:11]=2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH:1]1([CH2:4][O:5][C:6]2[C:7]([CH3:18])=[CH:8][C:9]([CH:12]=[O:13])=[N:10][CH:11]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 89875016HCID 89875016, compound

Product 1

HCID 89874839HCID 89874839, compoundYield 99%

Procedure

The title compound is prepared in >99% yield (495 mg, pale orange solid) from 5-(cyclopropylmethoxy)-N-methoxy-N,4-dimethylpicolinamide (622 mg, 2.49 mmol, Step-4) and lithium aluminum hydride (47 mg, 1.2 mmol) in a similar manner to Step-2 of Amine-3.

Sources & evidence

ORD record
ord-89b6c53ecc924a2383c73d7a034d7e6d
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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