HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanol → 5-Chloro-6-(cyclopropylmethoxy)pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 5,6-Dichloronicotinic acid | HCID 247987 | — |
| Product | 5-Chloro-6-(cyclopropylmethoxy)pyridine-3-carboxylic acid | HCID 28413957 | 98% |
Reaction Steps
The title compound is prepared in 98% yield (4.65 g, white solid) from 5,6-dichloronicotinic acid (4.00 g, 20.8 mmol) and cyclopropylmethanol (2.25 g, 31.3 mmol) in a similar manner to Step-1 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-6473b2f19cf541078a9f171579bc7b54 |
| Source note | uspto-grants-2015_11 |