HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,2-Difluoropropyl 1,1,1-trifluoromethanesulfonate → 2-Chloro-5-(2,2-difluoropropoxy)-4-methylpyridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,2-Difluoropropyl 1,1,1-trifluoromethanesulfonate | HCID 58747012 | — |
| Edukt | 2-Chloro-5-hydroxy-4-methylpyridine | HCID 71299549 | — |
| Produkt | 2-Chloro-5-(2,2-difluoropropoxy)-4-methylpyridine | HCID 89874424 | 98% |
Reaktionsschritte
The title compound is prepared in 98% yield (4.52 g, pale yellow oil) from 6-chloro-4-methylpyridin-3-ol (3.00 g, 20.9 mmol) and 2,2-difluoropropyl trifluoromethanesulfonate (11.9 g, 52.2 mmol) in a similar manner to Step-1 of Amine-49.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09187475B2 |
| Quelldatensatz | uspto-grants-2015_11 |
| ORD ID | ord-a430dcdf6aee4a718f5283143a6abae7 |
| Quellennotiz | uspto-grants-2015_11 |