Aluminium lithium hydride → HCID 89875029, compound

HRID 715462Notes

Reaction equation

HRID 715462 reaction equation
[F:1][C:2]([F:19])([CH3:18])[CH2:3][O:4][C:5]1[C:6]([CH3:17])=[CH:7][C:8]([C:11](N(OC)C)=[O:12])=[N:9][CH:10]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:19][C:2]([F:1])([CH3:18])[CH2:3][O:4][C:5]1[C:6]([CH3:17])=[CH:7][C:8]([CH:11]=[O:12])=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 89874614HCID 89874614, compound

Product 1

HCID 89875029HCID 89875029, compoundYield 99%

Procedure

The title compound is prepared in >99% yield (1.01 g, pale orange solid) from 5-(2,2-difluoropropoxy)-N-methoxy-N,4-dimethylpicolinamide (1.25 g, 4.57 mmol, Step-4) and lithium aluminum hydride (87 mg, 2.3 mmol) in a similar manner to Step-2 of Amine-3.

Sources & evidence

ORD record
ord-ea737d4148fe41e191eb3f6da10dbdb9
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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